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A systematic approach to SMB process model identification from SMB process data

Authors:Grofils Valerie, Université Libre de Bruxelles, Belgium
Levrie Caroline, Faculté Polytechnique de Mons, Belgium
Kinnaert Michel, Université Libre de Bruxelles, Belgium
Vande Wouwer Alain, Faculté Polytechnique de Mons, Belgium
Topic:8.4 Control of Biotechnological Processes
Session:Control of Biotechnological Processes
Keywords: Chemical industry, Parameter identification, Identifiability, Sensitivity analysis, Error estimation, Covariance matrix

Abstract

The simulated moving bed process is a continuous chromatographic separation process, which is important in various fields, from sugar to enantiomer separation. In this paper, a systematic approach to parameter identification of a kinetic SMB model is presented. In contrast to previous studies, identifiability and the influence of local minima are investigated from fictitious data obtained by simulation of different SMB processes at various operating conditions.