This paper deals with a catalytic continuous stirred tank reactor (CCSTR) example, modeled as a two-input constrained nonlinear system. Based on the Lyapunov-based linearization strategy, the saturation-type parameterized control design can reduce the effect of actuator subject to amplitude and rate constraints, and the integrated two-input control framework can ensure the asymptotic output regulation and robustness against unknown disturbances. Our results are illustrated via nu-merical simulation.