15th Triennial World Congress of the International Federation of Automatic Control
  Barcelona, 21–26 July 2002 
IDENTIFICATION OF PHARMACEUTICAL CRYSTALLIZATION PROCESSES
Mitsuko Fujiwara* David L. Ma* Timokleia Togkalidou*
Danesh K. Tafti* Richard D. Braatz*
* University of Illinois at Urbana-Champaign

A key bottleneck in the production of pharmaceuticals is in the formation of crystals from solution. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview of recent developments in the identification of pharmaceutical crystallization processes. This includes descriptions of recent activities in model identification, experimental design, and robustness analysis of pharmaceutical crystallization processes.
Keywords: Biotechnology, Chemical sensors, Computer simulation, Batch control, Distributed-parameter systems, Sensors, Estimation algorithms, Robust control, Optimal control, Nonlinear systems
Session slot T-Fr-A11: Pharmaceutical Process Control/Area code 7a : Chemical Process Control