Bioengineering |
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| Session 756 - Bioseparations and Downstream Bioprocessing II | |||
| Separation unit operations make up a critical portion of biologics downstream processes. Complexity inherently associated with biologics manufacture such as product heterogeneity and host impurities presents process challenges not typically encountered in small-molecule separations. With bioreactor titers increasing steadily over the last several years, production cost and operational pressures are shifting further to downstream. In addition, biological metabolites are still produced in relatively low amounts. The development of cost- and time-effective bioseparation and concentration unit ops is thus key to efficient downstream processes. This session will focus on highlighting the latest advances in bioseparations and downstream processing, aimed at cost reduction, improved efficiency, and shortend development time. Topics to be covered include, but are not limited to: Centrifugation; Crystallization, evaporation, and precipitation; Membrane-based separations; Adsorption and ion exchange; Extraction; Expanded-bed chromatography. | |||
| Chair: | Bruno F. Marques | ||
| CoChair: | Nihal Tugcu | ||
| CoSponsor(s): | Pharmaceuticals |
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| 756a | Analysis of Different Affinity Membranes for the Primary Capture Step in Antibody Manufacturing Cristiana Boi, Simone Dimartino, Giulio C. Sarti |
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| 756b | Polymeric Immunoglobulin Receptor-D1 Based Affinity Ligand for Igm Purification Satyen Gautam, Kai ChEe Loh |
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| 756c | A Rational Approach for the Design and Synthesis of Selective Displacers for the Chromatographic Purification of Proteins Srinavya Vutukuru, Sandesh D. Kate, Scott A. McCallum, Christopher J. Morrison, Steven M. Cramer, Ravi S. Kane |
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| 756d | A Non-Chromatographic Elp-Intein Based Protein Purification Technique: Application to Mammalian Expression System Wan-Yi Wu, David Wood |
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| Break |
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| 756e | Programmable Isoelectric Chromatofocusing and Its Application to Targeted Proteomics and Preparative Purification of Proteins Derek Y.C. Choy, Charles Haynes |
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| 756f | Post-Viral Inactivation Filtration for Impurity Removal in Biopharmaceutical Processes Jeffrey E. Galvin, David Maheu, Sushil Abraham |
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| 756g | Sulphated Cellulose Membranes – An Economic Virus Capturing Method for Influenza Virus Purification Lars Opitz, Nadine Solf, Udo Reichl, Michael W. Wolff |
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