Model Based Drug Delivery For Anesthesia

Authors:	Dua Pinky, Imperial College London, United Kingdom Dua Vivek, University College London, United Kingdom Pistikopoulos Efstratios N., Imperial College London, United Kingdom
Topic:	8.2 Modelling & Control of Biomedical Systems
Session:	Parameter Estimation and Kinetic Modelling II
Keywords:	Biomedical systems, modelling, compartmental model, anesthesia, multiple drug infusion, mean arterial pressure (MAP), bispectral index (BIS)

Abstract

In this work a compartmental model for delivery of drugs (isoflurane, dopamine and sodium nitroprusside) for anesthesia is presented. The key feature of this model is that mean arterial pressure and unconsciousness of the patient can be simultaneously regulated. A number of dynamic simulation experiments are carried out for the validation of the model.