A new mathematical index for the optimal control of drug doses in the treatment of AIDS
| Authors: | de Souza José A. M. Felippe, UBI - Universidade Beira Interior, Portugal
Caetano Marco A L, IBMEC - Faculdade de Administração e Economia, São Paulo, Brazil
Yoneyama Takashi, Aeronautics Technological Institute, Brazil |
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| Topic: | 8.2 Modelling & Control of Biomedical Systems |
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| Session: | Control Application to Life Medicine II |
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| Keywords: | Side-effects, therapeutic effects, AIDS, drugs, optimization |
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Abstract
A new quantitative index is proposed to assign a numerical value that reflects the compromise between the therapeutic and side effects during treatment of AIDS using drugs that are active against HIV. The model considers that the clinical conditions are related to the values of CD4+T cell counts and viral load. The therapeutic effect is associated with increase in the CD4+T cell counts, while the side effects are assumed related to the drug doses. The proposed index might be useful in computer programs for numerical evaluation and optimization of different types of drug administration schemes. Copyright © 2005 IFAC.
