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Parameter Estimation for a Biological System: Model and Experimentations

Authors:Lormel Corine, DGA/DCE/CTA, France, Metropolitan
Autrique Laurent, DGA/DCE/CTA, France, Metropolitan
Serra Jean-Jacques, DGA/DCE/CTA, France, Metropolitan
Claudet Bernard, University of Perpignan, France, Metropolitan
Topic:8.2 Modelling & Control of Biomedical Systems
Session:Parameter Estimation and Kinetic Modelling II
Keywords: Biomedical systems, Mathematical model, Parameter estimation, Optical properties, Thermal diffusivity, Partial differential equation.

Abstract

Temperature evolution and skin burn process in biological samples exposed to laser radiation are investigated in this communication. A one-dimensional multi-layered model is presented and transient temperature is numerically estimated using a finite difference method. A damage function corresponding to the extent of burn injury and using the Arrhenius assumptions is proposed. Two experimental benches are presented in order to estimate human skin optical and thermal properties.