Robust Performance in Biophysical Networks

Authors:	Doyle III Francis, UCSB, United States Stelling Joerg, ETH, Switzerland
Topic:	8.4 Control of Biotechnological Processes
Session:	Systems Biology
Keywords:	robustness analysis, systems biology, robust performance,circadian rhythm, signal transduction

Abstract

Robust performance, the attainment of a specified response underuncertainty, is a well studied problem in control engineering. Inthe field of systems biology, related problems are emerging fromthe quantitative analysis of complex biophysical networks. In thispaper, connections are made between the robust %performanceperformance questions in biology and engineering. Two examples areused to illustrate these ideas: (i) a signal transduction network,and (ii) the gene network responsible for circadian oscillations.