Glucose Regulation in Type 1 Diabetic Patients by a Multi-Doses Regimen
Abstract
In this paper several multi-doses control regimens are suggested fortype 1 diabetic patients. The suggested regimes are proposed basedon different insulin formulations. The insulin doses are assumed tobe infused by a subcutaneous injection in a three daily regimenprior to each meal. Mixing two types of insulin: rapid or short, andintermediate or long action, the basal and postprandial insulinproductions of the pancreas are reproduced. The performance in theglucose regulation is evaluated during a 10-day trial by open-loopand closed-loop simulation with a compartmental model.
