Identification and control of positive and compartmental systems applied to neuromuscular blockade

Authors:	Magalhães Hugo, University of Oporto - Faculty of Sciences, Portugal Mendonça Teresa, University of Oporto - Faculty of Sciences, Portugal Rocha Paula, Department of Mathematics - University of Aveiro, Portugal
Topic:	8.2 Modelling & Control of Biomedical Systems
Session:	Identification of Biomedical System Dynamics
Keywords:	Compartmental models, positive systems, neuromuscular blockade control, on-line identification

Abstract

The paper presents a positive control law for feedback stabilization of a particular compartmental system. The features of this system allow to show that the application of the control law leads the system not only to a mass balance but also to a state of equilibrium, thus enabling the tracking of a constant reference. This new approach is used in the framework of neuromuscular blockade control and is illustrated by a simulation study. The problem of embedding identification methods in this compartmental model control approach is also considered and analysed.