Identifying new drug targets to combat pathogenic infections: an interdisciplinary approach
| Authors: | Smets Ilse, Katholieke Universiteit Leuven, Belgium
Cappuyns Astrid, Katholieke Universiteit Leuven, Belgium
Bernaerts Kristel, Katholieke Universiteit Leuven, Belgium
De Keersmaecker Sigrid, Katholieke Universiteit Leuven, Belgium
De Moor Bart, Katholieke Universiteit Leuven, Belgium
Vanderleyden Jos, Katholieke Universiteit Leuven, Belgium
Van Impe Jan F.M., Katholieke Universiteit Leuven, Belgium |
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| Topic: | 8.4 Control of Biotechnological Processes |
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| Session: | From Drug Design to Production: Control Issues |
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| Keywords: | biomedical systems, biocontrol, mathematical models,optimal experiment design |
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Abstract
Todays’ medical treatments are faced with alarming resistance development of pathogenic bacteria, due to (amongst other factors) the abundant and often inappropriate use of antibiotics. The development of a novel class of antibiotics has therefore become a major research theme. This paper presents a conceptual overview of how this quest is tackled in a multidisciplinary fashion whenthe focus lies on detecting and understanding regulatory pathways that lead to virulence. The importance of well designed and controlled bioreactor experiments as well as the integration (into mathematical models) of data, collected at different levels and from different sources, will be stressed. Copyright 2005 IFAC.
