From the Business Consulting perspective today s Enterprise Integration challenge has considerably shifted to newer dimensions than what was practiced only a few years ago. In this author s extensive experience from Asia to Americas and from SMEs to MNCs, no company boss ever stops worrying about the return on investment or investment to create the share holder value. Against this environment and e-Supply Chain Management as a domain of the focus, this paper describes the methodology of doing the Business Cases with Case Studies to illustrate the how to Business Case and Blue Printing aspects of Enterprise Integration Technology.