The objective is to control the internal temperature of a continuous stirred tank reactor (CSTR) with jacket and analyze the potentiality that offers manipulating the thermodynamic conditions of the coolant flow. In this paper four predictive functional control (PFC) strategies are analyzed, two of them are conventionally structured by manipulating flow in one case and temperature of the jacket coolant in the other. The other two manipulate the enthalpic conditions of the coolant in a cascade form by setting flow and temperature optimally. The servo and regulator problem are analyzed including an statistical economic studio for defining the best control structure.