15th Triennial World Congress of the International Federation of Automatic Control
  Barcelona, 21–26 July 2002 
CONTROLLABILITY ANALYSIS OF THE CHEMOTHERAPY OF HIV/AIDS
A.M. Jeffrey, X. Xia and I.K. Craig
Department of Electrical, Electronic and Computer Engineering,
University of Pretoria, Pretoria 0002, South Africa,
e-mail: {mjeffrey,xxia,icraig}@postino.up.ac.za.

Using mathematical models that show the host-pathogen interaction of the immune system with the HIV virus, this paper identifies the extent to which the stages in the progression of HIV AIDS are controllable, given that the available treatment strategies are constrained. These constraints are the imperfect inhibition of the replication of the virus by the available drugs, undesirable side effects and the ability of the virus to become resistant to drugs. This paper shows how controllability analysis can be applied to HIV AIDS models to identify stages where therapy initiation can benefit the patient more.
Keywords: Controllability analysis, chemotherapy, HIV, biomedical, treatment
Session slot T-Mo-A20: Modelling and Control of Biochemical and Biological Sys/Area code 4c : Modelling and Control of Biomedical Systems