Blood is a vital source for delivering oxygen and nutrients to trillions of cells in the body; this makes the function of the cardiovascular system essential to our existence. In the last few years, research interests were directed to exploring its behaviour under different types of stresses, i.e. mental and physical. In this study, we propose a closed-loop model built around the cardiovascular system, and analyse it under physical-stress conditions. In this study, the three signals of interest are: blood pressure, heart rate, and respiration; our proposed model is based on the original Luczak model introduced back in 1975. Three neuro-fuzzy models were elicited and included in the overall control system for generating the blood pressure, heart rate and respiration signals. The estimated signals, generated during simulation, showed good fits when compared with the actual measurements.