15th Triennial World Congress of the International Federation of Automatic Control
  Barcelona, 21–26 July 2002 
MONITORING OF BATCH PHARMACEUTICAL FERMENTATIONS: DATA SYNCHRONIZATION, LANDMARK ALIGNMENT, AND REAL-TIME MONITORING
Cenk Ündey, Bruce A. Williams, and Ali Çinar1
Illinois Institute of Technology
Department of Chemical and Environmental Engineering
10 W 33rd Street, Chicago, IL, 60616 USA

Most batch pharmaceutical fermentations have successive phases of operation. Detection of process phase landmarks is important for improving the performance of process monitoring and control. This study considers techniques for adjustment of batch data lengths to match landmarks of phases during the progress of the batch. Time synchronization and landmark alignment techniques are presented and their integration with on-line monitoring is discussed through illustrative examples.
Keywords: On-line process monitoring, time alignment, curve registration, dynamic time warping

1Corresponding Author: (e-mail: cinar@iit.edu).
E-mail: undey@iit.edu
Session slot T-Fr-A11: Pharmaceutical Process Control/Area code 7a : Chemical Process Control