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IMPLEMENTATION PROCEDURE OF AN ADVANCED SUPERVISORY AND CONTROL STRATEGY IN THE PHARMACEUTICAL INDUSTRY
K. Preuss#, M.-V. Le Lann°,+, M. Cabassud^, G. Anne-Archard*
# engineo GmbH, Ginsheimer Str. 1, 65462 Gustavsburg (Mainz), Germany
Tel.:+49 (0) 61 34 / 55 74 6-2, Fax: +49 (0) 61 34 / 55 74 6-1, karlheinz.preuss@engineo.com
° LAAS - 7, Av. du Colonel Roche - 31077 Toulouse Cedex 4 - France
+ INSA, DGEI - 135, Avenue de Rangueil - 31077 Toulouse Cedex 4 - France
Tel.: +33 5 6155 98 16, Fax: +33 5 6155 98 00, mvlelann@laas.fr
^ Laboratoire de Génie Chimique CNRS UMR 5503
18, Chemin de la Loge - 31078 Toulouse Cedex 4 - France
* Sanofi-Synthelabo, Développement Chimique
195, route d’Espagne - 31036 Toulouse - France
This paper describes the different steps followed during the implementation procedure of a temperature controller and a supervisory controller in a SCADA to control two batch reactors of 60 l and 160 l size of an industrial pharmaceutical plant. These reactors are used to produce the first quantities of drugs needed to perform clinical tests. The chemical reactions involved are often changed (several a week). The different steps of the project will be presented : design of a new heating-cooling system, development of a dynamic simulation model, design of the predictive and supervisory controller (SCA), connection of the SCA to the SCADA, experimental validation according to GMP. This SCA has been daily used as the standard control system for more than one year.
Keywords: Industrial implementation, Batch reactor control, Pharmaceutical industry, Supervisory control, Predictive control
Session slot T-Fr-A11: Pharmaceutical Process Control/Area code 7a : Chemical Process Control
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