Microparticle-based glucose sensors with tunable response properties have been developed, which use an enzymatic reaction scheme and oxygen sensitive lumophores to transduce glucose levels to phosphorescence intensity. The sensing chemistry is immobilized in alginate-silica (“algilica”) microparticles and Layer-by-Layer (LbL) technique is used to form thin nanofilm coatings with precise thickness. The objective is to use these sensors for continuous, non-invasive glucose monitoring following implantation in the dermis. As our sensors are based on enzyme kinetics, their performance depends on reaction kinetics and the transport rates of the analytes (i.e., glucose and oxygen), which can be adjusted by varying the thickness and material properties of the ultrathin film coating. More specifically, the response range has been shown to increase through deposition of thicker films on the microparticles. Nevertheless, a 10-bilayer PAH/PSS film with 0.2 M NaCl (~ 40 nm thick) resulted in a response range of 0 – 200 mg/dL, which does not cover the full clinical range for glucose monitoring (0 – 600 mg/dL). Another route of increasing the response range of such sensors is to increase the rate of oxygen diffusion. This can be accomplished by using mesoporous silica microparticles (SBA-15), for which oxygen diffusion is much higher than algilica. Simulations show that using silica microparticles instead of algilica microparticles can increase the range of these sensors up to 600 mg/dL. To validate the estimates obtained from modeling, experiments will be performed and results will be presented in this paper.