Organic-inorganic hybrid materials are of interest for numerous technological problems as ideally they possess the desirable characteristics of both the inorganic and organic constituents. In the current work we will summarize our efforts to grow polypeptide chains directly from the surface of a variety of ordered mesoporous materials once suitably functionalized. Using amine-functionalized OMS materials we have found that it is possible to form nanocomposites of OMS-polypeptide materials using Leuch's NCAs that possess a high density of polypeptide chains covalently attached to the OMS surface. Nitrogen adsorption on these materials indicates a dramatic decrease of porosity as compared to the parent OMS phase. More specifically this talk will summarize our findings on several fronts, namely how 1) the surface amine loading, 2) monomer identity, 3) pore size and 4) pore topology influence the nature of the composite material obtained. Both porosimetry and spectroscopy data will be presented to interrogate the composite material obtained. We will also present preliminary data for these materials regarding their ability to perform chiral separations.