Bioengineering |
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| Session 242 - Protein Engineering I: Therapeutics | |||
| The ability to create proteins with desired properties is limited by our current understanding of the relationships between protein sequence, protein structure and protein function and by our current abilities to search sequence space in an efficient manner. This session seeks presentations on emerging topics and recent successes in both the understanding and engineering of protein form and function. Experimental and computational approaches that are of scientific, medical, and industrial significance are sought after. Possible areas of interest include, but are not limited to: computational design, directed evolution, protein mutations and modifications including non-natural amino acids, antibody or cytokine engineering, and protein medicinal chemistry. | |||
| Chair: | George Georgiou | ||
| CoChair: | Scott Banta | ||
| 242a | Affinity Maturation of Antibody Fragments Containing Non-Canonical Amino Acids James A. Van Deventer, Tae Hyeon Yoo, David A. Tirrell |
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| 242b | A Comparison of Antibodies Isolated from Immune Libraries by Two Different Anchored Periplasmic Expression (APEx) Systems Thomas J. Van Blarcom, Sean Carroll, Yariv Mazor, George Georgiou |
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| 242c | Synthetic Library Design Using the Fibronectin Domain as a Model System Benjamin J. Hackel, K. Dane Wittrup |
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| 242d | Developing Therapeutic Proteins by Engineering Ligand-Receptor Interactions Douglas S. Jones, Stayce E. Beck, Stephen S. Lee, Jennifer R. Cochran |
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| Break |
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| 242e | Novel Enzyme-Prodrug Therapy for Cancer Roger G. Harrison, Yahya A. Lazrak, Luis F.F. Neves, Peter S. McFetridge, Arafat Tfayli |
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| 242f | Fabrication of Engineered Collagen-Like Biopolymers Sam Wei Polly Chan, She-pin Hung, Richard Lathrop, Nancy A. Da Silva, Szu-Wen Wang |
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| 242g | Non-Associating Heterodimeric DNA Methyltransferases as a Platform for Developing Site-Specific Methyltransferases Glenna Meister, Srinivasan Chandrasegaran, Marc Ostermeier |
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