Session 504 - Protein Structure, Function and Stability I


Bioengineering
Session 504 - Protein Structure, Function and Stability I
We invite submissions in the areas of experimental, theoretical, and computational approaches to prediction, design, and/or optimization of protein structure, stability, and function. Studies may include structural analysis and engineering of proteins, creation or optimization of function, conformational analysis, analysis of thermal stability, mechanism of protein folding and misfolding, modes of protein degradation via physical and chemical routes, and other issues involving (over)expression, purification, and final biopharmaceutical product formulation. Reports of studies both in laboratory and processing settings relevant to all biotechnology products are welcome. Investigations of molecular pathways and mechanisms that provide insights into human diseases and potential treatments are of particular interest to this session.
Chair:	Sheldon Park
CoChair:	Peter M. Tessier
	504a	Synergetic Approach to Nonnative Aggregation by Multi-Assay Design of Experiments, Multivariate Statistics, and Mechanistic Kinetics Yi Li, Babatunde A. Ogunnaike, Christopher J. Roberts
	504b	Folding and Aggregation of Polyglutamine Peptides and Proteins Regina M. Murphy, Robert Walters, Matthew Tobelmann, Joseph Bernacki
	504c	Synthetic Prions Shed Light on Conformational Basis of Strain Diversity David Colby, Stanley Prusiner
	504d	Analysis of Protein Misfolding and Aggregation Using Peptide Microarrays Moumita Bhattacharya, Jason Lin, Sumitra Sukumaran, Jonathan Dordick, Peter M. Tessier
		Break
	504e	Computational Predictions of the Enzymatic Activity of Single Deletion Mutants Monica Berrondo, Jeffrey J. Gray
	504f	Computational Analysis and Design for Altered Cofactor Specificity George A. Khoury, Hossein Z. Fazelinia, Costas D. Maranas
	504g	Molecular Design of Therapeutic Antibodies with Enhanced Stability Naresh ChEnnamsetty, Vladimir Voynov, Veysel Kayser, Bernhard Helk, Bernhardt L. Trout

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