Engineering Fundamentals in Life Science |
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| Session 587 - Disease Therapies and Diagnostics I | |||
| Molecular and cellular science and engineering efforts over the past decade have given rise to numerous novel approaches for detecting and treating disease. These approaches have substantial potential for early detection and to provide highly specific and efficacious therapies for challenging disease targets (e.g. persistent pathogen infections, neurodegenerative disease and cancer). This session will highlight these creative approaches, including but not limited to biosensors, combination drug therapies, novel drug delivery systems (e.g. mechanisms to cross the blood-brain barrier), catalytic (e.g. proteolytic) therapies, nanotherapies, nucleic acid and RNA interference therapies, gene therapies, oncolytic viruses, cell and stem cell based therapies. Both discovery and development efforts, including therapeutic design approaches based on systems-level modeling, will be covered. Furthermore, translation of these ‘next generation’ therapeutics for the detection and treatment of specific disease targets will be emphasized. | |||
| Chair: | Sundararajan V. Madihally | ||
| CoChair: | Christa N. Hestekin | ||
| 587a | In Vivo Monitoring of Viral Proteolytic Activity Using Luminescent Quantum Dot FRET-Based Probes Divya Sivaraman, Marylynn V. Yates, Ashok Mulchandani, Wilfred ChEn |
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| 587b | Facile Size Isolation and Peptide Conjugation to Lipid-Coated Microbubbles: Application to Molecular Imaging of Renal Tumor Models Mark A. Borden, Jessica Kandel, Darrell Yamashiro |
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| 587c | Engineered Knottin Polypeptides. A New Class of In Vivo Molecular Imaging Agents Richard H. Kimura, Aron M. Levin, Zhen ChEng, Sanjiv Sam Gambhir, Jennifer R. Cochran |
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| 587d | “Aquaporin-1: Its Presence, Distribution and Quantification In Arterial Endothelium and How These Change with Chronic Hypertension – with Relevance to Early Atherogenesis” Jimmy Deon Toussaint, Tieuvi Nguyen, Stewart Russell, Kung-Ming Jan, David Rumschitzki |
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| Â | Break |
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| 587e | Quartz Crystal Microbalance Analysis of Growth Kinetics for Aggregation Intermediates of the Amyloid-β Protein Joseph A. Kotarek, Kathryn C. Johnson, Melissa A. Moss |
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| 587f | Engineering of Embryonic Stem Cell Neurogenic Differentiation for Neurodegenerative Diseases Daniel E. Kehoe, Ewa K. Stachowiak, Michal K. Stachowiak, Emmanuel (Manolis) S. Tzanakakis |
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| 587g | Optimization of An Enrichment Process for Circulating Tumor Cells from the Blood of Head and Neck Cancer Patients through Depletion of Normal Cells Liying Yang, James, Campbell Lang, Priya Balasubramanian, David Schuller, Amit Agrawal, Maciej Zborowski, Jeffrey J. Chalmers |
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