Engineering Fundamentals in Life Science |
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| Session 300 - Metabolic Engineering for Tissues and Organs | |||
| This session focuses on the development and application of metabolic engineering techniques and principles to mammalian systems, in the context of physiology and disease pathophysiology. Relevant topics include: (1) the characterization of pathway flux distributions in metabolic derangements of disease, such as diabetes, cancer, and hypercatabolic syndromes, etc.; (2) the development of nutritional, pharmacological, and other interventions to ameliorate these conditions; (3) the development of techniques to quantify fluxes in vivo, for example using mass balances, radiolabels, stable isotopes, etc.; (4) the development of techniques to elucidate the regulation of metabolic pathway networks using metabolomic, proteomic, and genomic information. | |||
| Chair: | Francois Berthiaume | ||
| CoChair: | Christina Chan | ||
| 300a | A Novel Control-Theoretic Approach for Modeling Metabolic Networks and Inferring Pathway Regulation Jamey D. Young, Kristene L. Henne, John A. Morgan, Allan E. Konopka, Doraiswami Ramkrishna |
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| 300b | Modeling Glycolysis and Mitochondrial Metabolic Processes In Pancreatic β-Cells Pradeep Nagaraja, Emmanuel (Manolis) S. Tzanakakis |
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| 300c | Unraveling the Role of Central Metabolism In Hepatic Lipoapoptosis Using 13C Flux Analysis and Comprehensive Metabolic Profiling Jamey D. Young, Yasushi Noguchi, Jose O. Aleman, Michael E. Hansen, Joanne K. Kelleher, Gregory Stephanopoulos |
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| 300d | Modulating the Lipoprotein-Dependent HCV Secretion Yaakov Nahmias, Jonathan Goldwasser, Monica Casali, Raymond Chung, Martin Yarmush |
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| Break |
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| 300e | Effects of Hormone and Amino Acid Supplementation In Optimal Liver Specific Functions of Hepatocytes Hong Yang, Charles M. Roth, M.G. Ierapetritou |
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| 300f | In Vivo Metabolic Fluxes In Rat Livers: Effect of Burn Injury Nripen S. Sharma, Maria-Louisa Izamis, Korkut Uygun, Francois Berthiaume, Martin Yarmush |
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| 300g | Endothelial Cells Augment Hepatocytes Function In An Organotypical Model of Liver Rohit Jindal, Yaakov Nahmias, Arno W. Tilles, Francois Berthiaume, Martin Yarmush |
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