Pharmaceuticals |
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| Session 432 - New Approaches In Upstream Bioprocessing: Development and Manufacturing | |||
| There are many challenges in the development of successful upstream processes. These include the development of processes that are amenable to scale-up, fundamental understanding of equipment design and operating parameters, as well as effective technology transfer. Compressed timelines pose additional challenges, necessitating efficient and coordinated process development. Topics such as the following are invited: • Novel systems for process development • Multi-product development using a standardized platform approach • Significance and impact of upstream and downstream development on each other • Approaches for scale-up/ technology transfer/ bioreactor design • Use of models for scale-up / scale-down | |||
| Chair: | Lori Herz | ||
| CoChair: | Seshu Tyagarajan | ||
| 432a | A Scalable 30 Ml Bioreactor for Biopharmaceutical Screening Mario M. Alvarez, David Bulnes-Abundis, Leydi Maribel Carrillo-Cocom, J. Manuel Aguilar-Yáñez, Keith Jhonson |
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| 432b | A 24-Well Plate Microbioreactor Array for High-Throughput Cell Culture Process Development Yuan Wen, Ning Liu, Xudong Zhang, Shang-Tian Yang |
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| 432c | Modeling the Platform: Leveraging Cross-Project Data to Understand Upstream Bioprocess Scale-up Brian J. Stamper |
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| 432d | Effect of Manufacturability Considerations In Facilitating Efficient Development and Transfer of An Escherichia Coli Process Producing Fc-Fusion Proteins Henry Lin, Heideh Barkhordarian, Irene Liu, Jonathan Lull |
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| Break |
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| 432e | Production of Growth Hormone Receptor Antagonist In Nicotiana Tabacum Cells: Process Development, Optimization, Scale-up and Technology Transfer Seshu Tyagarajan, Venkatesh Srinivasan |
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| 432f | Mammalian Cell Death Pathways Induced by Different Types of Shear Flow Timm Tanzeglock, Miroslav Soos, Gregory N. Stephanopoulos, Massimo Morbidelli |
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| 432g | Modeling Shear-Induced Cho Cell Death In Rotary Lobe Pump Hari Kamaraju, Kenneth Wetzel, William J. Kelly |
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