Session 607 - Modeling in the Pharmaceutical Industry I


Pharmaceuticals
Session 607 - Modeling in the Pharmaceutical Industry I
The development of pharmaceuticals involves the development of both process and chemistry/formulation to produce the active pharmaceutical ingredient/final drug product. We invite contributions from industry and academia that address system-level process simulation (cycle time analysis, mass and energy balances, equipment usage, scheduling etc.) and/or more detailed unit operations modeling during process development and scale-up in pharmaceutical synthesis and formulation (e.g. reaction steps, kinetics, solvent chasing, crystallization, filtration, drying). Particular consideration will be given to examples of model development from laboratory data with model validation during scale-up and clear savings or greater process understanding as a result of process modeling.
Chair:	Richard Schild
CoChair:	Christopher L. Burcham
	607a	Overview of Models Used in Design Space Determination: A Regulatory Perspective Sharmista Chatterjee
	607b	Reaction Kinetics for An API Process with Multiple Pathways and Hidden Intermediates David Willcox, Deepak Ahuja, Tim Towne, Wenke Li, Todd McDermott
	607c	An Application of Reaction Engineering and Modeling In Quality by Design Daniel Hallow, Justin Burt, Boguslaw Mudryk, Lucius Rossano, Srinivas Tummala
	607d	Ontology-Based Modeling Environment for Pharmaceutical Product Development: Milling Case Study Pavan Kumar Akkisetty, Pradeep Suresh, Gintaras V. Reklaitis, Venkat Venkatasubramanian
		Break
	607e	Mapping the Droplet Drying Phenomena within a Fluidized Bed Coater as a Prediction Tool for Coating Qualities Fesia L. Laksmana, Paul J.A. Hartman Kok, Herman Vromans, Henderik W. Frijlink, Kees Van der Voort Maarschalk
	607f	Use of Mathematical Models to Scale up Lyophilization Process Venkat R. Koganti, Sumit Luthra, Evgenyi Shalaev, Larry Gatlin
	607g	Magnetically Enhanced Centrifugation for Continuous Biopharmaceutical Processing Fei ChEn, Kenneth A. Smith, T. Alan Hatton

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Pharmaceuticals