References Bancroft, G. N., V. I. Sikavitsas and A. G. Mikos (2003). "Design of a flow perfusion bioreactor system for bone tissue-engineering applications." Tissue Engineering 9(3): 549-554. Chung, C. A., C. W. Yang and C. W. Chen (2006). "Analysis of cell growth and diffusion in a scaffold for cartilage tissue engineering." Biotechnology and Bioengineering 94(6): 1138-1146. Coletti, F., S. Macchietto and N. Nlvassore (2006). Mathematical modelling of three-dimensional cell cultures in perfusion bioreactors. Part II. Computer Aided Chemical Engineering., Elsevier. 21: 1699-1704. de Tremblay, M., M. Perrier, C. Chavarie and J. Archambault (1993). "Fed-batch culture of hybridoma cells: comparison of optimal control approach and closed loop strategies." Bioprocess Engineering 9(1): 13-21. Frahm, B., P. Lane, H. Märkl and R. Pörtner (2003). "Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis." Bioprocess and Biosystems Engineering 26(1): 1-10. Galban, C. J. and B. R. Locke (1999). "Analysis of cell growth kinetics and substrate diffusion in a polymer scaffold." Biotechnology and Bioengineering 65(2): 121-132. Hossain, M. S., D. J. Bergstrom and X. B. Chen (2015). "Modelling and simulation of the chondrocyte cell growth, glucose consumption and lactate production within a porous tissue scaffold inside a perfusion bioreactor." Biotechnology Reports 5(1): 55-62. Kiparissides, A., M. Koutinas, C. Kontoravdi, A. Mantalaris and E. N. Pistikopoulos (2011). "‘Closing the loop’ in biological systems modeling — From the in silico to the in vitro." Automatica 47(6): 1147-1155. Lee, Y. Y., M. Yap, W.-S. Hu and K. Wong (2003). "Low-Glutamine Fed-Batch Cultures of 293-HEK Serum-Free Suspension Cells for Adenovirus Production." Biotechnology progress 19: 501-509. Lin, T. H., C. H. Lin and C. A. Chung (2011). "Comutational study of oxygen and glucose transport in engineered cartilage constructs." Journal of Mechanics 27(3): 337-346. Martin, I., D. Wendt and M. Heberer (2004). "The role of bioreactors in tissue engineering." Trends in Biotechnology 22(2): 80-86. Paim, Á., N. Cardozo, P. Pranke and I. Tessaro (2019). "SENSITIVITY ANALYSIS FOR MODEL COMPARISON AND SELECTION IN TISSUE ENGINEERING." Brazilian Journal of Chemical Engineering 36: 383-391. Schmid, J., S. Schwarz, R. Meier-Staude, S. Sudhop, H. Clausen-Schaumann, M. Schieker and R. Huber (2018). "A Perfusion Bioreactor System for Cell Seeding and Oxygen-Controlled Cultivation of Three-Dimensional Cell Cultures." Tissue Eng Part C Methods 24(10): 585-595. Warren, S. M., A. M. Sailon, A. C. Allori, E. H. Davidson, D. D. Reformat and R. J. Allen Jr (2009). "A novel flow-perfusion bioreactor supports 3D dynamic cell culture." Journal of Biomedicine and Biotechnology 2009. Zhou, W., J. Rehm, A. Europa and W. S. Hu (1997). "Alteration of mammalian cell metabolism by dynamic nutrient feeding." Cytotechnology 24(2): 99-108.